Ulus Travma Acil Cerrahi Derg. Baskýdaki Makaleler: UTD-48409 | DOI: 10.14744/tjtes.2024.48409

Osteoporozun Tanýsýnda, Ýzleminde ve Patolojik Kýrýklarýnda Kemik Döngüsü Belirteçlerinin Rolü

Kazým Ersin Altýnsoy¹, Beytullah Unat^2
1Gaziantep Ýslam Bilim ve Teknoloji Üniversitesi, Týp Fakültesi, Acil Týp Anabilim Dalý, Gaziantep, Türkiye
²Gaziantep Þehir Hastanesi, Ortopedi ve Travmatoloji Kliniði, Gaziantep, Türkiye

Burada, geleneksel teþhis yöntemlerine kýyasla c-terminal telopeptid (CTX), n-telopeptid (NTX), deoksipiridinolin (DPD) ve tartrat rezorpsiyonunun (TRAP) spesifik biyobelirteçlerinin kullanýmýný araþtýrdýk. Bu yeni biyobelirteçlerin osteoporozun tanýsý, tedavisi ve izlenmesinde önemli deðer taþýyabileceðini varsaydýk. Çalýþma, 1 Ocak 2020'den 1 Ocak 2023'e kadar uzanan üç yýllýk bir dönemde gerçekleþtirildi. Osteoporoz tanýsý konan 50 yaþ ve üzeri toplam 520 hastayý kaydettik. Osteoporoza katkýda bulunduðu bilinen steroid tedavisi gören hastalar çalýþma dýþý býrakýldý. Ek olarak, osteoporoz tanýsýyla ilgili demografik özelliklere dayalý olarak 500 hastadan oluþan bir kontrol grubunu dikkatle seçip eþleþtirdik. Bu titiz seçim süreci, 1020 hastadan oluþan kapsamlý bir kohortla sonuçlandý. Çalýþma boyunca hastalar, patolojik kýrýklarýn oluþumunu izlemek ve genel prognozlarýný deðerlendirmek için bir yýl boyunca yakýndan izlendi. Titiz araþtýrmamýzýn sonucunda CTX, NTX, DPD ve TRAP'ýn kemik saðlýðýnýn deðerlendirilmesinde, tedavi etkinliðinin izlenmesinde ve osteoporoz baðlamýnda patolojik kýrýklarýn tespitinde önemli rol oynayan önemli biyobelirteçler olduðunu belirledik. Sonuç olarak çalýþmamýz, bu biyobelirteçlerin osteoporozun teþhis ve tedavisini ilerletmedeki öneminin altýný çizerek hastalýðýn ilerlemesi ve tedavi sonuçlarý hakkýnda deðerli bilgiler sunmaktadýr.

Anahtar Kelimeler: Osteoporoz, C-terminal telopeptid (CTX), N-telopeptid (NTX), Deoksipiridinolin (DPD) ve Tartrat rezorpsiyonu (TRAP)

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The Role of Bone Turnover Markers in Diagnosis, Monitoring, and Pathological Fractures of Osteoporosis

Kazým Ersin Altýnsoy¹, Beytullah Unat^2
1Department of Emergency Medicine, Faculty of Medicine, Gaziantep Islam Science and Technology University, Gaziantep, Turkey
²Department of Orthopedics and Traumatology, Gaziantep City Hospital, Gaziantep, Turkey

Here, we have investigated the utility of specific biomarkers, namely, c-terminal telopeptide (CTX), n-telopeptide (NTX), deoxypyridinoline (DPD), and tartrate resorption (TRAP), in comparison to conventional diagnostic methods. We hypothesized that these novel biomarkers could hold substantial value in the diagnosis, treatment, and monitoring of osteoporosis. The study was conducted over a three-year period, spanning from January 1, 2020, to January 1, 2023. We enrolled a total of 520 patients aged 50 years or older who had been diagnosed with osteoporosis. Patients who were undergoing steroid treatments, which are known to contribute to osteoporosis, were excluded from the study. Additionally, we carefully selected and matched a control group consisting of 500 patients based on demographic characteristics relevant to the diagnosis of osteoporosis. This meticulous selection process resulted in a comprehensive cohort comprising 1020 patients. Throughout the study, patients were closely monitored for a duration of one year to track the occurrence of pathological fractures and assess their overall prognosis. As a result of our rigorous investigation, we have identified CTX, NTX, DPD, and TRAP as pivotal biomarkers that play a crucial role in evaluating bone health, monitoring treatment effectiveness, and detecting pathological fractures in the context of osteoporosis. In conclusion, our study underscores the significance of these biomarkers in advancing the diagnosis and management of osteoporosis, offering valuable insights into the disease's progression and treatment outcomes.

Keywords: Osteoporosis, C-terminal telopeptide (CTX), N-telopeptide (NTX), Deoxypyridinoline (DPD), and Tartrate resorption (TRAP)

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