YANIKTA N�TR�K OKS�T �RET�M�N�N DESTEKLENMES� VEYA AZALTILMASININ �SKEM�K HASARI AZLTMADAK� ROL�

Zilan, Ayd�n; �etinkale, O�uz; K�ran, Bayram; �nl��erci, Ye�im; Olga�, Vakur; Deniz, G�nnur; Bekp�nar, Selda

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YANIKTA N�TR�K OKS�T �RET�M�N�N DESTEKLENMES� VEYA AZALTILMASININ �SKEM�K HASARI AZLTMADAK� ROL� [Ulus Travma Acil Cerrahi Derg]

Ulus Travma Acil Cerrahi Derg. 2003; 9(3): 169-175

YANIKTA N�TR�K OKS�T �RET�M�N�N DESTEKLENMES� VEYA AZALTILMASININ �SKEM�K HASARI AZLTMADAK� ROL�

Ayd�n Zilan¹, O�uz �etinkale², Bayram K�ran³, Ye�im �nl��erci⁴, Vakur Olga�⁵, G�nnur Deniz³, Selda Bekp�nar⁴
¹B�y�k�ehir Belediyesi, Sa�l�k ��leri M�d�rl�� ehzade T�p Merkezi, �stanbul, Turkey
²�stanbul �niversitesi Cerrahpa�a T�p Fak�ltesi Plastik ve Rekonstr�ktif Cerrahi Anabilim Dal�, �stanbul, Turkey
³�stanbul �niversitesi Detae, �mmunoloji Anabilim Dal�, �stanbul, Turkey
⁴�stanbul �niversitesi �stanbul T�p Fak�ltesi, Biyokimya Anabilim Dal�, �stanbul, Turkey
⁵�stanbul �niversitesi Onkoloji Enstit�s�, Patoloji B�l�m�, �stanbul, Turkey

THE ROLE OF SUPPLEMENTATION OR INHIBITION OF NITRIC OXIDE PRODUCTION IN BURN INJURY TO REDUCE ISCHEMIC DAMAGE

Background: To determine the role of nitric oxide (NO) which is vasodilator agent and inflammatory cytokine, in burn injury.
Methods: Rats were divided into 5 groups, and a 30 % burn was inflicted. In addition to sham control and burn control groups, other 3 groups were given L-Arginin, and L-nitro-L-Arginine methylester (L-NAME), and both. Neutrophil and hematocrit percentage in blood, NO, TNF-alfa and malondialdehyde (MDA) levels in plasma and neutrophil
infiltration in the lung were evaluated at 24 hours after thermal injury.
Results: The inhibition of NO production with L-NAME treatment significantly decreased these parameters when compared to burned control group. MDA was decreased significantly in all groups which were given drugs.
Conclusion: The induction and inhibition of NO production both reduced lipid peroxidation but induction increased the mortality, plasma TNF-alfa and neutrophil in the blood. Inhibition of NO production is found more useful after thermal injury in rats.

Keywords: burn, nitric oxide, burn shock, lipid peroxidation

Makale Dili: T�rk�e

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