Serbest prefabrike poröz polietilen implant flebi ile ortotopik üç boyutlu doku rekonstrüksiyonu modeli
Orhan Murat Özdemir1, Savaş Serel2, Serdar Gökrem3, Arda Katırcıoğlu4, Zeki Can4, Sibel Serin51Kırıkkale Yükses İhtisas Hastanesi Plastik, Rekonstrüktif ve Estetik Cerrahi Kliniği, Kırıkkale2Ankara Üniversitesi Tıp Fakültesi, Plastik, Rekonstrüktif ve Estetik Cerrahi Anabilim Dalı, Ankara
3Sağlık Bakanlığı Ankara Eğitim ve Araştırma Hastanesi Plastik, Rekonstrüktif ve Estetik Cerrahi Kliniği, Ankara
4Serbest Hekim, Ankara
5Ankara Üniversitesi Tıp Fakültesi, Histololoji ve Embriyoloji Anabilim Dalı, Ankara
Three-dimensional orthotopic tissue reconstruction with a free, prefabricated high-density porous polyethylene implant flap
Orhan Murat Özdemir1, Savaş Serel2, Serdar Gökrem3, Arda Katırcıoğlu4, Zeki Can4, Sibel Serin51Kırıkkale Yükses İhtisas Hastanesi Plastik, Rekonstrüktif ve Estetik Cerrahi Kliniği, Kırıkkale2Ankara Üniversitesi Tıp Fakültesi, Plastik, Rekonstrüktif ve Estetik Cerrahi Anabilim Dalı, Ankara
3Sağlık Bakanlığı Ankara Eğitim ve Araştırma Hastanesi Plastik, Rekonstrüktif ve Estetik Cerrahi Kliniği, Ankara
4Serbest Hekim, Ankara
5Ankara Üniversitesi Tıp Fakültesi, Histololoji ve Embriyoloji Anabilim Dalı, Ankara
BACKGROUND: We investigated the appropriateness of the implant to be used in free-tissue transfers in a rabbit model in which a full-thickness skin graft was wrapped around a prefabricated high-density porous polyethylene implant.
METHODS: In ten New Zealand white rabbits, high-density porous polyethylene implants (Medpor), 10x15x3 mm in size, were bilaterally placed and anchored underneath the superficial inferior epigastric artery and vein pedicle under anesthesia. The flaps were prefabricated through vascular induction. Eight weeks later, the flaps were wrapped by a full-thickness postauricular skin graft, following orthotopic transplantation. Two weeks after grafting, full-thickness biopsy samples were obtained from the distal
one-third of the implants and stained with hematoxylin-eosin and Masson trichrome for histologic examination.
RESULTS: Graft compliance was observed in all the implants. Histologic sections showed rich fibro-neovascular tissue, neovascularization, and development of connective tissue cells. There were very few polymorphonuclear cells. No signs of inflammation were observed.
CONCLUSION: Prefabrication of the high-density porous polyethylene implant under the superficial inferior epigastric artery and vein results in sufficient conditions for its use in free transfers.
Makale Dili: Türkçe