Ulus Travma Acil Cerrahi Derg. 2024; 30(4): 242-247 | DOI: 10.14744/tjtes.2024.67520

The role of ischemia-modified albumin, presepsin, delta neutrophil index, and inflammatory markers in diagnosing acute cholecystitis

Muhammed Semih Gedik¹, Ali Ihsan Kilci¹, Hakan Hakkoymaz¹, Muhammed Seyithanoðlu², Muhammed Alperen Orakçý³, Nuri Mehmet Basan⁴, Arif Aksu⁵, Ömer Faruk Küçük^1
1Department of Emergency Medicine, Sütçü Ýmam University Faculty of Medicine, Kahramanmaraþ-Türkiye
²Department of Medical Biochemistry, Sütçü Ýmam University Faculty of Medicine, Kahramanmaraþ-Türkiye
³Department of General Surgery, Kayseri State Hospital, Kayseri-Türkiye
⁴Department of Neurology, Baþakþehir Çam ve Sakura State Hospital, Ýstanbul-Türkiye
⁵Department of Emergency Medicine, Adana State Hospital, Adana-Türkiye

BACKGROUND: The purpose of this study is to determine the significance of markers such as C-reactive protein, procalcitonin, complete blood count parameters, delta neutrophil index, ischemia-modified albumin, presepsin, and oxidative stress indicators, which are associated with inflammation, oxidative stress, and ischemia in the pathology and diagnosis of acute cholecystitis in adults.
METHODS: Patients diagnosed with acute cholecystitis in the emergency department and healthy individuals in the control group were included in the study. Routine blood count and biochemistry analyses were performed on the participants. Blood serum was used to measure ischemia-modified albumin, presepsin, and oxidative stress indicators.
RESULTS: White blood cell count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, delta neutrophil index, C-reactive protein, procalcitonin, ischemia-modified albumin, ischemia-modified albumin to albumin ratio, presepsin, and oxidative stress indicators were significantly higher in patients with cholecystitis compared to the control group. Measurements of white blood cell count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and delta neutrophil index can be included as part of the complete blood count. The complete blood count parameters are readily available and do not incur additional costs to the healthcare system.
CONCLUSION: The authors believe that the neutrophil-to-lymphocyte ratio, delta neutrophil index, ischemia-modified albumin, ischemia-modified albumin to albumin ratio, and presepsin values can be used as new markers in the diagnosis of acute cholecystitis due to their high sensitivity, specificity, and low negative likelihood ratio.

Keywords: Acute cholecystitis, delta neutrophil index; ischemia-modified albumin; neutrophil-to-lymphocyte ratio; presepsin.

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Akut kolesistit tanýsýnda iskemik modifiye albümin, presepsin, delta nötrofil indeksi ve inflamatuar belirteçlerin rolü

Muhammed Semih Gedik¹, Ali Ihsan Kilci¹, Hakan Hakkoymaz¹, Muhammed Seyithanoðlu², Muhammed Alperen Orakçý³, Nuri Mehmet Basan⁴, Arif Aksu⁵, Ömer Faruk Küçük^1
1Sütçü Ýmam Üniversitesi Týp Fakültesi, Acil Týp Ana Bilim Dalý, Kahramanmaraþ, Türkiye
²Sütçü Ýmam Üniversitesi Týp Fakültesi, Týbbi Biyokimya Ana Bilim Dalý, Kahramanmaraþ, Türkiye
³Kayseri Þehir Hastanesi, Genel Cerrahi Kliniði, Kayseri, Türkiye
⁴Baþakþehir Çam ve Sakura Þehir Hastanesi, Nöroloji Kliniði, Ýstanbul, Türkiye
⁵Adana Þehir Hastanesi, Acil Týp Kliniði, Adana, Türkiye

AMAÇ: Eriþkinlerde akut kolesistit tanýsýnda C-reaktif protein, prokalsitonin, tam kan sayýmý parametreleri, delta nötrofil indeksi, iskemik modifiye albümin, presepsin, oksidatif stres göstergeleri gibi inflamasyon, oksidatif stres ve iskemi ile iliþkili belirteçlerin patolojideki yerini belirlemektir.
GEREÇ VE YÖNTEM: Çalýþmaya acil serviste akut kolesistit tanýsý alan hastalar ve saðlýklý kontrol grubu dahil edildi. Çalýþmaya alýnan hastalara rutin kan sayýmý ve biyokimya tetkikleri yapýldý. Ýskemik modifiye albümin, presepsin ve oksidatif stres göstergelerini ölçmek için kan serumu kullanýldý.
BULGULAR: Lökosit sayýsý, nötrofil/lenfosit oraný, trombosit/lenfosit oraný, delta nötrofil indeksi, C-reaktif protein, prokalsitonin, iskemik modifiye albümin, iskemik modifiye albümin/albümin oraný, presepsin ve oksidatif stres göstergeleri deðerleri akut kolesistit tanýlý hastalar da kontrol grubu ile karþýlaþtýrýldýðýnda anlamlý olarak yüksek saptandý.
SONUÇ: Nötrofil/lenfosit oraný, delta nötrofil indeksi, iskemik modifiye albümin, iskemik modifiye albümin/albümin oraný ve presepsin deðerlerinin yüksek duyarlýlýk, özgüllük ve düþük negatiflik olasýlýðý oranlarý nedeniyle akut kolesistit tanýsýnda yeni belirteçler olarak kullanýlabileceðine inanýyoruz.

Anahtar Kelimeler: Akut kolesistit, Ýskemik modifiye albümin, Presepsin, Nötrofil/lenfosit oraný, Delta nötrofil indeksi.

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