Ulus Travma Acil Cerrahi Derg. 2023; 29(8): 929-934 | DOI: 10.14744/tjtes.2023.40652

Placebo-controlled randomized double-blind comparison of the analgesic efficacy of lidocaine spray and etofenamate spray in pain control of rib fractures

Safa Dönmez¹, Ahmet Burak Erdem³, Alp Þener², Furkan Altas¹, Reyhan Ýrem Mutlu^1
1Department of Emergency, Ankara Bilkent City Hospital, Ankara-Türkiye
²Emergency Service, Ankara Etlik City Hospital, Ankara-Türkiye
³Department of Emergency Medicine, Ankara Yýldýrým Beyazýt University, Faculty of Medicine, Ankara-Türkiye

BACKGROUND: As far as we could detect, we could not find any study in literature on the analgesic efficacy of spray forms of lidocaine and etofenamate in rib fractures. In this study, our aim is to empirically compare the analgesic efficacy of etofenamate spray, lidocaine 10% spray and placebo spray in the management of pain secondary to trauma secondary to isolated rib fractures.
METHODS: The study was designed according to a single-center, prospective, randomized, placebo-controlled double-blind study model. About 30 sealed envelopes were prepared for each of the 3 groups and 30 patients were included in each group. A total of 84 cases were included in the study (three groups: 27, 28, 29).
RESULTS: Numeric rating scale (NRS) grades at admission and at 15-30-60-120 min were similar between the three groups (P>0.05). Analysis findings of NRS perception differences between the initial NRS level and the 15-30-60-120th min NRS difference at the 0–120th min showed more lidocaine spray organs, and it was not clearly perceived that these four parameters went between the 3 groups for the outline.
CONCLUSION: The analgesic efficacy of lidocaine 10% spray, etofenamate spray, and placebo spray used together with standard dexketoprofen 50 mg intravenous treatment in the pain management of rib fractures were similar to each other and although there was a difference at the 120th min, this difference was not statistically significant.

Keywords: Emergency department, etofenamate spray, lidocaine spray, pain; rib fractures.

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Kot kýrýklarýnýn aðrý kontrolünde lidokain sprey ve etofenamat spreyin analjezik etkinliðinin plasebo kontrollü randomize çift kör karþýlaþtýrmasý

Safa Dönmez¹, Ahmet Burak Erdem³, Alp Þener², Furkan Altas¹, Reyhan Ýrem Mutlu^1
1Ankara Bilkent Þehir Hastanesi, Acil Servis, Ankara, Türkiye
²Ankara Etlik Þehir Hastanesi, Acil Servis, Ankara, Türkiye
³Ankara Yýldýrým Beyazýt Üniversitesi, Týp Fakültesi, Acil Týp Anabilim Dalý, Ankara, Türkiye

AMAÇ: Tespit edebildiðimiz kadarý ile literatürde lidokain ve etofenamatýn sprey formlarýnýn kot kýrýðýndaki analjezik etkinliðine dair bir araþtýrmaya rastlamadýk. Bu çalýþmada amacýmýz, ampirik olarak travmaya sekonder izole kot kýrýðýna baðlý aðrý yönetiminde etofenamat sprey, lidokain %10 sprey ve plasebo spreyin analjezik etkinliklerini karþýlaþtýrmaktýr.
GEREÇ VE YÖNTEM: Araþtýrma tek merkezli, prospektif, randomize, plasebo kontrollü çift kör araþtýrma modeline göre tasarlandý. Her 3 grup için 30’ar kapalý zarf hazýrlanmýþ ve her gruba 30 hasta alýndý. Çalýþmaya alýndýktan sonra çalýþmadan çýkarýlan vakalar sonrasýnda toplam 84 olgu çalýþmaya alýndý [üç grup: 27, 28, 29].
BULGULAR: Üç grup arasýnda baþvurudaki ve 15-30-60-120. dakikalardaki NRS dereceleri benzer bulundu [p>0.05]. Baþlangýçtaki NRS düzeyi ile 15-30-60-120. dakikalardaki NRS düzeyleri farklarý analiz edildiðinde 0-120. dakika NRS farký lidokain sprey grubunda daha fazla olmakla beraber bu dört parametrenin hiçbiri için 3 grup arasýnda istatistiksel olarak anlamlý bir farklýlýk saptanmadý.
SONUÇ: Kot kýrýðýnýn aðrý yönetiminde standart uygulanan deksketoprofen 50 mg intravenöz tedavi ile birlikte kullanýlan lidokain %10 sprey, eto-fenamat sprey ve plasebo spreyin analjezik etkinlikleri birbirlerine benzer çýktý ve 120. dakikada bir fark oluþsa da bu fark istatistiksel olarak anlamlý bulunmadý.

Anahtar Kelimeler: Kot Fraktürleri, acil servis, lidokain sprey, etofenamat sprey, aðrý.

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