Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study

BACKGROUND
We aimed to compare the effects of topical zinc oxide and topical silver sulfadiazine in the treatment of partial-thickness burn wounds.
METHODS
The study was conducted with 20 New Zealand rabbits, and burn wounds were created by a brass probe. The animals were randomly divided into two groups. The burns were treated with zinc oxide (Group O) or silver sulfadiazine (Group S) with daily application. The wound healing process was followed both clinically and histopathologically. We determined the days at which 50% and 80% re-epithelization was observed.
RESULTS
The mean time for 50% and 80% re-epithelization was 21.4 and 25.4 days in Group O and 25.8 and 30.2 days in Group S, respectively (p<0.001). The mean score for wound colonization was lower in Group O. The difference was statistically significant at weeks 2, 3, 4, and 6 (p<0.001). In the histopathological examination, the thicknesses of the epidermis, dermis and scar tissue were 0.12 mm, 3.80 mm and 244 mm in Group O, and 0.16 mm, 4.76 mm and 3.16 mm in Group S, respectively (p<0.001).
CONCLUSION
In this experimental burn study, zinc oxide was more effective than silver sulfadiazine in terms of epithelization, dermis maturation and scar formation.

Yanýk yarasý tedavisinde topikal çinko oksit ile gümüþ sülfadiazinin karþýlaþtýrýlmasý: Deneysel çalýþma

AMAÇ
Bu çalýþmada, yanýk yaralarýnda yaygýn olarak kullanýlan çinko oksit ve gümüþ sülfadiazinin tedavi etkileri karþýlaþtýrýldý.
GEREÇ VE YÖNTEM
Yeni Zelanda cinsi 20 tavþanda pirinç propla yanýk yarasý oluþturuldu. Tavþanlar rastgele iki gruba ayrýldý. Yanýklar günlük uygulamayla birinci grupta çinko oksitle (Grup O), ikinci grupta (Grup S) gümüþ sülfadiazinle tedavi edildi. Yara iyileþmesi klinik ve histopatolojik olarak takip edildi. Yara ölçümleri yapýldý ve %50 ve %80 reepitelizasyona ulaþtýðý günler belirlendi.
BULGULAR
Ortalama %50 ve %80 reepitelizasyona ulaþma süreleri Grup O’da sýrasýyla 21,4 ve 25,4 gün, Grup S’de 25,8 ve 30,2 gündü (p<0,001). Yara kolonizasyonu ise 1, 2, 3, 4, 5 ve 6. haftalarda ortalama olarak Grup O’da daha düþüktü. Fark 2, 3, 4 ve 6. haftalarda anlamlý idi (p<0,001). Histopatolojik deðerlendirme sonucunda Grup O’da epidermis, dermis ve skar dokusunun kalýnlýklarý sýrasýyla 0,12, 3,80 ve 2,44 mm idi. Grup S’de ise 0,16, 4,76 ve 3,16 mm olarak bulundu (p<0,001).
SONUÇ
Bu deneysel çalýþmada, çinko oksit yanýk tedavisinde epitelizasyon, epidermis maturasyonu ve skar oluþumunda gümüþ sülfadiazinden daha etkili bulunmuþtur.