THE EFFECT OF HETEROLOGOUS COLLAGEN IN NEOCHONDROGENESIS FROM FREE PERICHONDRIAL GRAFTS, IN RABBITS: AN EXPERIMENTAL STUDY

Background: After chondrogenic potential of perichondrium was recognized, perichondrial grafts have been used in reconstruction of cartilage defects. Enhancing neochondrogenesis has many advantages, in this regard. This experimental study was done in the aim of identifying whether the heterologous collagen has an accelerating effect on neochondrogenesis from perichondrial grafts or not.
Methods: We placed perichondrial grafts, onto the dorsal muscles of twelve white New-Zealand rabbits, on both sides. On one side, heterologous collagen sponge was inserted between the graft and the muscle, the other side served as a control.
Results: As a result of histological assessment on days 45, 120 and 180, we obtained that heterologous collagen enhanced the neochondrogenesis.
Conclusion: We believe that, if any cartilage defect would be reconstructed with a Perichondrial graft, additional use of heterologous collagen will be helpful.

TAVÞANLARDA PERÝKONDRÝUM GREFTLERÝNDEN YENÝ KIKIRDAK OLUÞUMUNA HETEROLOG KOLLAJENÝN ETKÝSÝ