AIMS: In this study. the effect of an extra-lung sepsis model on lung histopathology is evaluated.
METHODOLOGY: In this study 20 Wistar-Albino rats were used. Following the ether anesthesia laparotomy was done. Caecum was ligated by a silk thread and was perforated by 18 gauge needle. It is squeezed untill feces emerged. Abdominal wall is closed. By this method peritoneal sepsis was perfor/ned. The rats are divided into two groups (n: 1 0). 0.5 ml of serum physiologic is applied to the control group, and imipenem is applied to the antibiotic group as 15 mg/kg/ tid. 48 hours later rats were sacrificied by extreme ether anesthesia.Relaparatomy was done and diaphragm was open. Multiple biopsies were made from the lung. Biopsy materials was cultured and examined histopathologically.
RESULTS: In control group; rats died in 48 hours (%100),but antibiotic group were alive (%0). The results of lung biopsy cultures are; in all rats in control group, Escherichia coli (E. coli) and Bacteriodes fragilis (B.fragilis) were cultured (% 100). Whereas in antibiotic group there is no bacteria cultured (p< 0.001). Histopathologic results are: in control group there was wide spread edema and congestion and inflammatory reaction. In antibiotic group there was slight edema, congestion and inflammatory reaction.
CONCLUSION: In septic condition sings of adult respiratory distress syndrome occurs. Large spectrum antibiotics can prevent nd bacterial translocation in lungs and could minimize the lung injury.