Timokinonun akut periferik sinir hasar� �zerine akut etkisi:  Deneysel bir �al��ma

G�l�en, �smail; Ak, Hakan; Kara, Mikail; G�kalp, Abdulsemat; Akyol, Veysel; Ko�ak, �mer Faruk; Ra�betli, Murat �etin

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Timokinonun akut periferik sinir hasar� �zerine akut etkisi: Deneysel bir �al��ma [Ulus Travma Acil Cerrahi Derg]

Ulus Travma Acil Cerrahi Derg. 2016; 22(6): 526-530 | DOI: 10.5505/tjtes.2016.40204

Timokinonun akut periferik sinir hasar� �zerine akut etkisi: Deneysel bir �al��ma

�smail G�l�en¹, Hakan Ak², Mikail Kara³, Abdulsemat G�kalp⁴, Veysel Akyol³, �mer Faruk Ko�ak⁵, Murat �etin Ra�betli³
¹Y�z�nc� Y�l �niversitesi T�p Fak�ltesi, Beyin Ve Sinir Cerrahisi Ana Bilim Dal�, Van
²Bozok �niversitesi T�p Fak�ltesi, Beyin Ve Sinir Cerrahisi Ana Bilim Dal�, Yozgat
³Y�z�nc� Y�l �niversitesi T�p Fak�ltesi, Histoloji Ve Embriyoloji Ana Bilim Dal�, Van
⁴Bitlis Tatvan Devlet Hastanesi, Beyin Ve Sinir Cerrahisi, Bitlis
⁵Y�z�nc� Y�l �niversitesi T�p Fak�ltesi, Plastik Ve Rekonstruktif Cerrahi Ana Bilim Dal�, Van

AMA�: Bu �al��man�n amac� akut sinir hasar�nda timokinonun akut d�nem etkilerini de�erlendirmektir.
GERE� VE Y�NTEM: �al��ma s��an sinirinde siyatik sinirde ezilme modeli geli�tirilerek yap�ld�. S��anlar kontrol, travma ve timokinon tedavi grubu olmak �zere �� gruba ayr�ld� (n=6). Sinir hasar�ndan yedi g�n sonra hasar yerinden siyatik sinir doku �rnekleri al�nd�. Bu doku �rneklerinde histolojik ve steryolojik �al��ma yap�ld�. Akson �ap�, myelin kal�nl�� ve akson yo�unluk �l��mleri yap�ld�.
BULGULAR: Gruplar aras�nda akson �ap�, miyelin kal�nl�� ve akson yo�unlu�u bak�m�ndan anlaml� bir farkl�l�k g�r�lmedi.
TARTI�MA: Timokinon akut sinir hasar� �zerinde akut d�nemde iyile�tirici etkiye sahip de�ildir.

Anahtar Kelimeler: Akson, akson yo�unlu�u, miyelin kal�nl��, siyatik sinir; timokinon.

The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study

�smail G�l�en¹, Hakan Ak², Mikail Kara³, Abdulsemat G�kalp⁴, Veysel Akyol³, �mer Faruk Ko�ak⁵, Murat �etin Ra�betli³
¹Department Of Neurosurgery, Y�z�nc� Y�l University, Van, Turkey
²Department Of Neurosurgery, Bozok University, Yozgat, Turkey
³Department Of Histology, Y�z�nc� Y�l University, Van, Turkey
⁴Department Of Neurosurgery, Tatvan State Hospital, Bitlis, Turkey
⁵Department Of Plastic And Reconstructive Surgery, Y�z�nc� Y�l University, Van, Turkey

BACKGROUND: The purpose of this study was to evaluate the acute effects of thymoquinone (TQ) on acute nerve injury.
METHODS: A rat model of crush injury of the sciatic nerve was used. Animals were divided into 3 groups: control, trauma, and TQ treatment groups (n=6 per group). Seven days after injury, sciatic nerve specimens were obtained from the site of the injury and analyzed histologically and stereologically. Axon diameter, myelin thickness, and axon density were measured.
RESULTS: There were no significant differences in axon diameter, myelin thickness, or axon density among groups.
CONCLUSION: TQ has no acute therapeutic effect on acute nerve injury.

Keywords: Axon wdensity, myelin thickness, sciatic nerve, thymoquinone.

�smail G�l�en, Hakan Ak, Mikail Kara, Abdulsemat G�kalp, Veysel Akyol, �mer Faruk Ko�ak, Murat �etin Ra�betli. The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study. Ulus Travma Acil Cerrahi Derg. 2016; 22(6): 526-530

Sorumlu Yazar: �smail G�l�en, T�rkiye
Makale Dili: �ngilizce

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