Akut apandisitte toplam oksitadif durum, toplam antioksidan durum ve paraoksonaz enzim aktivitesi

AMAÇ: Bu çalýþmanýn amacý, akut apandisit tanýsý alan hastalarda toplam okstadif durum, toplam antioksidan durum deðerleri ile paraoksonaz enzim aktivitesinin araþtýrýlmasýdýr.
GEREÇ VE YÖNTEM: Ameliyat öncesi akut apandisit tanýsýyla ameliyata alýnan 73 hasta (Grup I) ile kontrol grubu olarak (Grup II) saðlýklý 30 kiþi çalýþmaya alýndý. Patolojik inceleme sonucunda hastalar: 1) Akut fokal apandisit, 2) Akut ilerlemiþ apandisit (süpüratif, flegmenöz ve gangrenöz apandisit), 3) Akut perfore apandisit, 4) Subakut apandisit ve 5) Negatif eksplorasyon olarak sýnýflandýrýldý. Paraoksonaz enzim aktivitesi, toplam okstadif durum, toplam antioksidan durum deðerleri için kan örnekleri ameliyat öncesinde alýndý.
BULGULAR: Hastalarýn toplam oksidatif ve antioksidatif durum düzeyleri kontrol grubuna göre yüksekti. Paraoksonaz enzim aktivitesi karþýlaþtýrýldýðýnda grup I ile II arasýnda herhangi bir anlamlý fark saptanmadý. Akut perfore apandisitli hastalarýn toplam oksidatif ve antioksidatif durum düzeyleri hem akut fokal apandisitli hem de akut ilerlemiþ apandisitli hastalardan daha yüksek bulundu.
TARTIÞMA: Toplam oksidatif ve antioksidatif durum düzeylerinin akut apandisitli hastalarda enflamasyonun ilerlemesi ile artmaktadýr

Total oxidant status, total antioxidant status, and paraoxonase activity in acute appendicitis

BACKGROUND: The aim of this study was to investigate the levels of oxidative stress including total oxidant status, total antioxidant status, and paraoxonase activity in patients with a diagnosis of acute appendicitis.
METHODS: Seventy-three patients who underwent surgery with a preoperative diagnosis of acute appendicitis (Group I) were included into the study. The control group (Group II) consisted of thirty otherwise healthy subjects. After histopathologic examination, the patients were categorized as follows: 1) Acute focal appendicitis, 2) Acute advanced appendicitis including acute suppurative, phlegmonous and gangrenous appendicitis, 3) Acute perforated appendicitis, 4) Sub-acute appendicitis, and 5) Negative exploration.
Blood samples for paraoxonase activities, and total oxidant and antioxidant status levels were obtained preoperatively.
RESULTS: Total oxidant and antioxidant status of the patients in the acute appendicitis group were higher than those of the control group. When paraoxonase activities of Group I was compared with Group II, no significant difference was determined. Both total oxidant and antioxidant status levels of acute perforated appendicitis were higher than those of both acute focal appendicitis and acute advanced appendicitis.
CONCLUSION: The increase in the oxidative status (total oxidant and antioxidant status) was related with the progression of inflammation to the perforation in acute appendicitis.