Effect of curcumin on lung injury induced by skeletal muscle ischemia/reperfusion in rats [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. Ahead of Print: UTD-83616 | DOI: 10.5505/tjtes.2018.83616  

Effect of curcumin on lung injury induced by skeletal muscle ischemia/reperfusion in rats

Hamed Ashrafzadeh Takhtfooladi1, Mohammad Ashrafzadeh Takhtfooladi2
1Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
2Young Researchers and Elites Club, Science and Research Branch, Islamic Azad University, Tehran, Iran.

BACKGROUND: This study was conducted to investigate effects of curcumin on lung damage following ischemia reperfusion injury following hind limb ligation.
METHODS: Forty Wistar rats were divided into 4 groups of sham (G1), I/R (G2), curcumin plus sham (G3), and curcumin plus I/R (G4). Curcumin was administered (200 mg/kg) daily for 2 weeks before the study. I/R was induced by placement of rubber tourniquets at greater trochanters for 2 hours, followed by reperfusion for 4 hours.
RESULTS: Curcumin pretreatment significantly decreased the level of malondialdehydes and increased the level of superoxide dismutase in lung tissues (P < 0.05), compared to the I/R group. Glutathione peroxidase activity was not significantly different among the groups (P > 0.05). I/R caused severe histopathological injury (P < 0.05), including inflammatory cell infiltration and intraalveolar hemorrhage.
CONCLUSION: These results suggest that curcumin pretreatment has protective effects against lung injury induced by muscle I/R.

Keywords: Curcumin, Skeletal muscle, Ischemia/reperfusion, Lung.




Corresponding Author: Mohammad Ashrafzadeh Takhtfooladi, Iran


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