Comparison of the effects of Punica granatum flower extract and silver sulfadiazine on wound healing in rats with burn injury [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. Ahead of Print: UTD-76891 | DOI: 10.5505/tjtes.2017.76891  

Comparison of the effects of Punica granatum flower extract and silver sulfadiazine on wound healing in rats with burn injury

Ebrahim Nasiri1, Seyed Jalal Hosseinimehr2, Jafar Akbari3, Mohammad Azadbakht1, Soheil Azizi2
1Traditional and Complementary Medicine Research Center, Mazandaran University of Medical
2Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran
3Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

BACKGROUND: Burn injuries are associated with many complications such as extended hospitalization, complicated operative procedures, and even death. Punica granatum Linn (Punicaceae) is used to treat various diseases, including infections.
We compared the efficacy of P. granatum flower extract with that of silver sulfadiazine (SSD) for treating thermal burn injuries in rats.
METHODS: Flowers of P. granatum were used to prepare the hyrdoalocholic extract. Ten Wistar rats in each group were topically administrated base cream, normal saline, cream containing 1% SSD, or creams containing 5% or 10% P. granatum flower extract. The treatments were administered once daily until complete wound healing was observed. The wound area and healing time were assessed. In addition, percentage wound contraction and histopathological characteristics such as neovascularization and collagen formation were determined. The tannin content in P. granatum extract was determined.
RESULTS: The decrease in the average size of wounds on day 15 of the treatment was higher in rats treated with creams containing P. granatum flower extract than in rats treated with cream containing 1% SSD (2.8 ± 0.9 cm2 versus 8.4 ± 3.2 cm2). The wounds completely healed on day 25 of the treatment in rats treated with creams containing P. granatum flower extract compared with those in rats treated with the other agents. The results showed that P. granatum extract was containing high concentration (48.7%) of tannin.
CONCLUSION: These results indicated that P. granatum flower extract promoted wound healing in rats and could be used for managing burn injuries.

Keywords: Wound healing time, herbal medicine, histopathology, tannins, percentage of wound contraction




Corresponding Author: Seyed Jalal Hosseinimehr, Iran


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