Diagnostic and prognostic value of procalcitonin and phosphorus in acute mesenteric ischemia

BACKGROUND
In this study, using an animal model of acute mesenteric ischemia (AMI), we investigated the possible use of procalcitonin and phosphorus in the early diagnosis of AMI.
METHODS
In this study, 21 New Zealand rabbits were used. Subjects were allocated into three groups as Control, Sham and Ischemia. No intervention was performed in the subjects in the Control group. In the subjects in the Sham and Ischemia groups, laparotomy was performed with midline incision. In the Ischemia group, the superior mesenteric artery was found and tied after laparotomy. Blood was drawn from the animals in all groups at 0, 1, 3 and 6 hours, and procalcitonin and phosphorus levels were studied in these samples.
RESULTS
In the Ischemia group, the increase in the levels of serum phosphorus and procalcitonin was found to be statistically significant compared to the Control and Sham groups (p<0.05). The levels of phosphorus and procalcitonin were detected to increase from the 1st hour after ischemia onset, and the increase continued for the following 6 hours (p<0.05).
CONCLUSION
Phosphorus and procalcitonin may be important parameters for use in the early diagnosis and prognosis of AMI.

Akut mezenter iskemide prokalsitonin ve fosforun tanýsal ve prognostik deðeri

AMAÇ
Akut mezenter iskemi (AMÝ) modeli kullanýlarak yapýlan bu çalýþmada, serum prokalsitonin ve fosfor düzeylerinin AMÝ erken tanýsýnda kullanýlabilirliði araþtýrýldý.
GEREÇ VE YÖNTEM
Çalýþmada 21 adet Yeni Zelanda tavþaný kullanýldý. Denekler Kontrol, Sham ve Ýskemi grubu olarak adlandýrýldý. Kontrol grubundaki deneklere herhangi bir giriþim yapýlmadý. Sham ve Ýskemi grubundaki deneklere orta hat insizyonu ile laparotomi yapýldý. Ýskemi grubundaki deneklere ise laparatomi yapýldýktan sonra süperior mezenterik arter bulunarak baðlandý. Her üç gruptaki hayvanlardan 0., 1., 3. ve 6. saatlerde kan alýndý, bu numunelerden prokalsitonin ve fosfor çalýþýldý.
BULGULAR
Ýskemi grubunda, serum fosfor ve prokalsitonin düzeylerindeki yükselme kontrol ve sham gruplarýna göre istatistiksel olarak anlamlý bulundu (p<0,05). Fosfor ve prokalsitonin düzeylerinin, iskemi oluþturulduktan sonra 1. saatten itibaren arttýðý ve bu yüksekliðin 6 saat boyunca devam ettiði saptandý (p<0,05).
SONUÇ
Fosfor ve prokalsitonin’in AMÝ’nin erken tanýsýnda ve prognozunda kullanýlabilecek önemli parametreler olabileceðini düþünüyoruz.