The histopathological investigation of the effect on regional and systemic tissues of the application of Medicinal Plant Extract Ankaferd Blood Stopper in deep tissue injuries in Rats [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. 2013; 19(1): 1-7 | DOI: 10.5505/tjtes.2013.65642  

The histopathological investigation of the effect on regional and systemic tissues of the application of Medicinal Plant Extract Ankaferd Blood Stopper in deep tissue injuries in Rats

Mehmet Okumuş1, Kasım Zafer Yüksel2, Davut Özbağ3, Harun Çıralık4, Zeki Yılmaz2, Yakup Gümüşalan3, Vedat Bakan5, Ali Murat Kalender6
1Department Of Emergency Medicine, Sutcu Imam University, Kahramanmaras, Turkey
2Department Of Neurosurgery, Sutcu Imam University, Kahramanmaras, Turkey
3Department Of Anatomy, Sutcu Imam University, Kahramanmaras, Turkey
4Department Of Pathology, Sutcu Imam University, Kahramanmaras, Turkey
5Department Of Pediatric Surgery, Sutcu Imam University, Kahramanmaras, Turkey
6Department Of Orthopedics And Traumatology, Sutcu Imam University, Kahramanmaras, Turkey

Purpose:
This study was planned to evaluate the hystopathological changes under light microscope when the ABS (mixture of five plant extracts) was applied in deep tissue hemorrhage and the systemic organ effects as animal study model.
Materials and Methods:
A total of 50 Wistar Albino rats were divided into 5 groups each consisting 10 rats. The rats underwent femoral vein puncture and treated with ABS tampon, ABS spray, Surgicel and one group left untreated. After 2 weeks, each group underwent partial tissue excision in the same femoral region and as well as from brain, heart, kidney and liver.
Results:
The specimens from all group was obtained from femoral region after two weeks and evaluated under light microscope. The light microscope revealed any histopathological changes on neurovascular structures or in deep connective tissues in all groups.
Conclusions:
Ankaferd Blood Stopper provided hemostasis and was observed to stop bleeding. There were any hystopathological changes in tissue level and no pathological effects in other organs tissues under light microscope, the remote organ tissue remain clear.

Keywords: Ankaferd, ABS, Blood stopper, Deep tissue injury, Hemostasis.


Mehmet Okumuş, Kasım Zafer Yüksel, Davut Özbağ, Harun Çıralık, Zeki Yılmaz, Yakup Gümüşalan, Vedat Bakan, Ali Murat Kalender. The histopathological investigation of the effect on regional and systemic tissues of the application of Medicinal Plant Extract Ankaferd Blood Stopper in deep tissue injuries in Rats. Ulus Travma Acil Cerrahi Derg. 2013; 19(1): 1-7

Corresponding Author: Mehmet Okumuş, Türkiye


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