The efficacy of a hemostatic agent in anticoagulant drug-induced rat bleeding model [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. 2014; 20(2): 79-85 | DOI: 10.5505/tjtes.2014.54938  

The efficacy of a hemostatic agent in anticoagulant drug-induced rat bleeding model

Ertan Sönmez1, Umut Yücel Çavuş3, Cemil Civelek1, Ali Dur1, Eda Karayel1, Bedia Gulen1, Ömer Uysal2, Göktürk İpek4
1Department Of Emergency Medicine, Bezmialem Vakıf University, İstanbul, Turkey
2Department Of Biostatistics, Bezmialem Vakıf University, İstanbul, Turkey
3Department Of Emergency Medicine, Dışkapı Yıldırım Beyazıt E.a. Hospital, Ankara, Turkey
4Department Of Cardiology, Siyami Ersek E.a. Hospital, Istanbul, Turkey

Background
Bleeding is the major problem in warfarin pretreated patients especially who need emergency surgerical procedures. APH is a hemostatic agent with ultra-hydrophilic and particulate properties. This study aimed to evaluate the in vivo hemostatic effect of APH in rats pretreated with warfarin.
Methods
Forty eight Wistar rats were divided into two main groups: one group was pretreated with warfarin and the other group was not. These two groups was further divided into 3 subgroups according to the administration of APH, wheat meal or saline, for a total of 6 subgroups. Standard full thickness tissue defects were performed on the back of the rats. Saline, wheat meal or APH were administered to the bleeding defect site in both main groups. Haemostasis time and amount of bleeding were calculated.
Results
The bleeding time in rats administered APH was significantly shorter than those administered wheat meal and saline and consequently amount of bleeding was significantly less than those of the control groups.
Conclusion
APH has an effective hemostatic property in rats pretreated or non-pretreated with anticoagulants. Hemostatic agents can be usefull for external bleedings which are growing because of anticoagulation.

Keywords: rat, warfarin, hemostatic


Ertan Sönmez, Umut Yücel Çavuş, Cemil Civelek, Ali Dur, Eda Karayel, Bedia Gulen, Ömer Uysal, Göktürk İpek. The efficacy of a hemostatic agent in anticoagulant drug-induced rat bleeding model. Ulus Travma Acil Cerrahi Derg. 2014; 20(2): 79-85

Corresponding Author: Ertan Sönmez, Türkiye


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