Effect of β-glucan on serum level of IL-12, hs-CRP and clinical outcomes in Multiple trauma patients: a prospective randomized study [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. Ahead of Print: UTD-34514 | DOI: 10.5505/tjtes.2017.34514  

Effect of β-glucan on serum level of IL-12, hs-CRP and clinical outcomes in Multiple trauma patients: a prospective randomized study

Zahra Vahdat Shariatpanahi1, Zakyeh Fazilaty1, Hamid Chenari2
11National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
22Department of Anesthesiology and Critical Care, Haftometir Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: Trauma is associated with a profound immunological dysfunction. This predisposes patients to infections and adverse outcomes. β-glucan have been implicated in the initiation of anti-microbial immune response. Aim of this study was to evaluate the effects of an enteral diet containing β-glucan on serum levels of IL-12 and highly-sensitive C-reactive protein (hs-CRP), occurrence of infection and clinical outcomes in critically ill multiple trauma patients.
Methods: Forty multiple trauma patients expected to require enteral nutrition for at least 10 days were randomly assigned to the intervention group (n=20) or the placebo group (n=20). The intervention group received a high-protein enteral diet providing 3 g β-glucan, and control group received a similar diet except for 3 g of maltodextrin as a placebo. Serum levels of IL-12 and hs-CRP were measured on days 0, 10, and 21.
Results: β-glucan group showed significantly higher serum levels of IL-12 on day 21 compared to the control group. Infection frequency and Duration of mechanical ventilation were significantly lower in the β-glucan group. A significant difference was found in the Sequential Organ Failure Assessment Score (SOFA score) in favor of the β-glucan group. We did not find any difference in the serum levels of hs-CRP, length of ICU stay, occurrence of infection and mortality rates between the two groups
Conclusion: β-glucan may increase serum levels of IL-12, may shorten duration of mechanical ventilation, and may reduce organ failure in critically ill multiple trauma patients.

Keywords: Enteral Nutrition, ICU, Prebiotic, Infection


Effect of β-glucan on serum level of IL-12, hs-CRP and clinical outcomes in Multiple trauma patients: a prospective randomized study

Zahra Vahdat Shariatpanahi1, Zakyeh Fazilaty1, Hamid Chenari2
11National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
22Department of Anesthesiology and Critical Care, Haftometir Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: Trauma is associated with a profound immunological dysfunction. This predisposes patients to infections and adverse outcomes. β-glucan have been implicated in the initiation of anti-microbial immune response. Aim of this study was to evaluate the effects of an enteral diet containing β-glucan on serum levels of IL-12 and highly-sensitive C-reactive protein (hs-CRP), occurrence of infection and clinical outcomes in critically ill multiple trauma patients.
Methods: Forty multiple trauma patients expected to require enteral nutrition for at least 10 days were randomly assigned to the intervention group (n=20) or the placebo group (n=20). The intervention group received a high-protein enteral diet providing 3 g β-glucan, and control group received a similar diet except for 3 g of maltodextrin as a placebo. Serum levels of IL-12 and hs-CRP were measured on days 0, 10, and 21.
Results: β-glucan group showed significantly higher serum levels of IL-12 on day 21 compared to the control group. Infection frequency and Duration of mechanical ventilation were significantly lower in the β-glucan group. A significant difference was found in the Sequential Organ Failure Assessment Score (SOFA score) in favor of the β-glucan group. We did not find any difference in the serum levels of hs-CRP, length of ICU stay, occurrence of infection and mortality rates between the two groups
Conclusion: β-glucan may increase serum levels of IL-12, may shorten duration of mechanical ventilation, and may reduce organ failure in critically ill multiple trauma patients.

Anahtar Kelimeler: Enteral Nutrition, ICU, Prebiotic, Infection




Corresponding Author: Zahra Vahdat Shariatpanahi, Türkiye


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