Role of Angiotensin converting enzyme as prognostic marker in thoracic trauma: a prospective observational study. [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. Ahead of Print: UTD-14894 | DOI: 10.5505/tjtes.2018.14894  

Role of Angiotensin converting enzyme as prognostic marker in thoracic trauma: a prospective observational study.

Suresh Kumar1, Ajay Kumar Pal1, Arvind Kumar Suman1, Sanjeev Kumar1, Ganesh Chandra Yadav1, Mohd. Kaleem Ahmad2
1Department Of Surgery, King George's Medical University, Lucknow, India
2Deapartment Of Biochemistry, King George's Medical University, Lucknow, India

Introduction: Chest injuries, accounting for 25% of all trauma related deaths is one of the main causes of death in young adults. Our priority is early identification of life threatening injuries both immediate and delayed. Role of various biomarkers such as CC 16, vWF, IL-6, TNF and Angiopoietin have been studied in trauma related ARDS (Adult respiratory distress syndrome). Serum ACE levels have been studied in non-trauma related ARDS. We planned a prospective observational study to evaluate the role of Angiotensin convertase enzyme as prognostic marker in thoracic trauma.
Material and methods: A prospective observational study was done to evaluate serum ACE levels in thoracic trauma patients and explore its prognostic potential with regards to clinical outcome.
Results: A total of 48 thoracic trauma patients were included in the study. Mean ACE levels in study population was 66.54±11.18. Strong positive correlation was found among serum ACE levels and TTSS (Thoracic trauma severity score).
Conclusion: Our study demonstrates that serum ACE levels are raised in thoracic trauma patients with higher levels indicating severe nature of trauma in concordance with increased TTSS scores.

Keywords: Injury, Chest, ACE, Marker, Prognosis.




Corresponding Author: Sanjeev Kumar, India


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