Association of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with in-hospital mortality in the early phase of severe trauma [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. Ahead of Print: UTD-02516 | DOI: 10.14744/tjtes.2020.02516  

Association of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with in-hospital mortality in the early phase of severe trauma

Dong Hun Lee1, Byung Kook Lee1, Sung Min Lee1, Yong Soo Cho1, Seong Woo Yun2
1Department Of Emergency Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Korea.
2Department of Emergency Medical Technology, Namseoul University, 91 Daehak-ro, Seonghwan-eup, Seobuk-gu, Cheonan, Chungnam, Republic of Korea

BACKGROUND: This study aimed to examine the relationship between the immediate and early complete blood count-based scores and prognosis in trauma patients.
METHODS: This retrospective observational study included adult patients admitted for severe trauma between January 2014 and December 2018. Multivariate logistic regression analysis was conducted to assess the association between the neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and platelet-to-lymphocyte ratio (PLR), and in-hospital mortality.
RESULTS: Among the 288 patients included in the study, in-hospital mortality was 26.4% (n = 76). Immediately after emergency department (ED) arrival, non-survivors had lower NLR (3.28 vs. 4.73) and PLR (55.73 vs. 87.21) and higher LMR (4.91 vs. 3.91) than survivors. At six hours after ED arrival, non-survivors had lower NLR (4.98 vs. 8.37) and PLR (58.23 vs. 123.74) and higher LMR (2.88 vs. 1.69) than survivors. Results of multivariate regression analysis revealed that NLR (odds ratio [OR], 0.926; 95% confidence interval [CI], 0.881–0.973) and PLR (OR, 0.994; 95% CI, 0.990–0.998) at six hours after ED arrival were independently associated with in-hospital mortality.
CONCLUSION: Lower NLR and PLR at six hours after ED arrival were associated with in-hospital mortality in cases of severe trauma.

Keywords: Trauma, prognosis, neutrophil-to-lymphocyte ratio




Corresponding Author: Byung Kook Lee, South Korea


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