THE EFFECTS OF LACTATED RINGERíS RESUSCITATION ON TISSUE BLOOD FLOWS AND OXIDANT INJURY IN EXPERIMENTAL CRUSH INJURY IN RATS [Ulus Travma Acil Cerrahi Derg]
Ulus Travma Acil Cerrahi Derg. 2003; 9(4): 239-245

THE EFFECTS OF LACTATED RINGERíS RESUSCITATION ON TISSUE BLOOD FLOWS AND OXIDANT INJURY IN EXPERIMENTAL CRUSH INJURY IN RATS

Veysel Balcż1, Halil Ozguc2, Sule Akkose1, Nevzat Kahveci3, Zehra Serdar4, Rifat Tokyay2
1Uludag University, Faculty of Medicine, Department of Emergency Medicine, Bursa, Turkey
2Uludag University, Faculty of Medicine, Department of Surgery, Bursa, Turkey
3Uludag University, Faculty of Medicine, Department of Physiology, Bursa, Turkey
4Uludag University, Faculty of Medicine, Department of Biochemistry, Bursa, Turkey

Background: In an experimental model of crush injury, tissue blood flow, the extend of oxidant injury and the effect of lactated ringerís resuscitation were investigated.
Methods: Rats were divided into sham (n: 8), crush injury (n: 8), and crush injury + lactated ringerís resuscitation (n: 8) groups. Arterial and venous cathetherization were performed in all groups. Crush injury was done with intravenous infusion of allogenic muscle extract. In the crush injury + lactated ringerís resuscitation group 30 ml/kg lactated ringerís solution was infused in 30 minutes. Kidney and liver blood flow were measured by using a laser flowmeter.
To assess the oxidant injury blood, liver, and kidney tissue samples were collected for malondialdehyde and glutathione measurements.
Results: In the crush injury, diminished liver and kidney blood flow rates were improved with lactated ringerís resuscitation.
In addition, glutathione levels decreased whereas malondialdehyde levels and base deficit increased. Lactated ringerís resuscitation brought base deficit to the control levels. When compared with the crush injury, lactated ringerís infusion increased the glutathione levels but could not decrease the malondialdehyde ones.
Conclusion: Lactated ringerís resuscitation improved the blood flow rates but could not prevent oxidant injury totally.

Keywords: Crush injury, glutathione, malondialdehyde, lactated ringerís.


DENEYSEL CRUSH YARALANMADA R›NGER LAKTAT RESUS›TASYONUNUN DOKU KAN VE OKS›DAN HASARA ETK›S›

Veysel Balcż1, Halil Ozguc2, Sule Akkose1, Nevzat Kahveci3, Zehra Serdar4, Rifat Tokyay2
1Uludag University, Faculty Of Medicine, Department Of Emergency Medicine, Bursa, Turkey
2Uludag University, Faculty Of Medicine, Department Of Surgery, Bursa, Turkey
3Uludag University, Faculty Of Medicine, Department Of Physiology, Bursa, Turkey
4Uludag University, Faculty Of Medicine, Department Of Biochemistry, Bursa, Turkey



Veysel Balcż, Halil Ozguc, Sule Akkose, Nevzat Kahveci, Zehra Serdar, Rifat Tokyay. THE EFFECTS OF LACTATED RINGERíS RESUSCITATION ON TISSUE BLOOD FLOWS AND OXIDANT INJURY IN EXPERIMENTAL CRUSH INJURY IN RATS. Ulus Travma Acil Cerrahi Derg. 2003; 9(4): 239-245


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